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J Autism Dev Disord. 2018 Oct;48(10):3629-3636. doi: 10.1007/s10803-018-3618-6.

Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum.

Author information

1
Sct. Hans Hospital, Mental Health Center Capital Region of Denmark, Institute of Biological Psychiatry, Boserupvej 2, 4000, Roskilde, Denmark. sonja.labianca@regionh.dk.
2
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark. sonja.labianca@regionh.dk.
3
Child and Adolescent Mental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
4
Departments of Clinical Medicine, Aalborg University, Aalborg, Denmark.
5
Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark.
6
Sct. Hans Hospital, Mental Health Center Capital Region of Denmark, Institute of Biological Psychiatry, Boserupvej 2, 4000, Roskilde, Denmark.
7
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark.
8
Psychiatric Specialist Clinic, Copenhagen, Denmark.

Abstract

Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) frequently co-occur and show high genetic correlation. With the introduction of DSM-5, there is a new concept of an ASD and/or ADHD spectrum (ASD/ADHD). This study aimed to identify predictors of severity and need of healthcare within this spectrum. 39 families with multiple individuals affected by ASD/ADHD were recruited from a psychiatric clinic. Diagnoses, functional and demographic characteristics were retrieved from journals while hospital admissions were identified in the Danish health register. An estimated fraction of 31% ASD/ADHD patients had never been hospitalized and 35% remained undiagnosed despite hospitalization. Cluster analysis identified trajectories that discriminate age of diagnosis, educational attainment to degree of severity, need of hospitalization and genetic risk.

KEYWORDS:

ADHD; ASD; Clusters of life trajectories; Co-morbidity; Genetic risk; National Health Register

PMID:
29882106
DOI:
10.1007/s10803-018-3618-6

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