Send to

Choose Destination
Clin Transl Immunology. 2018 May 31;7(6):e1018. doi: 10.1002/cti2.1018. eCollection 2018.

Genome-wide association studies of multiple sclerosis.

Author information

Departments of Neurology and Genetics Yale School of Medicine New Haven CT USA.
Broad Institute of MIT and Harvard Cambridge MA USA.


Large-scale genetic studies of multiple sclerosis have identified over 230 risk effects across the human genome, making it a prototypical common disease with complex genetic architecture. Here, after a brief historical background on the discovery and definition of the disease, we summarise the last fifteen years of genetic discoveries and map out the challenges that remain to translate these findings into an aetiological framework and actionable clinical understanding.


disease risk genetics; genome‐wide association studies; immune‐mediated disease; multiple sclerosis

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center