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Front Immunol. 2018 May 24;9:1070. doi: 10.3389/fimmu.2018.01070. eCollection 2018.

Betaine in Inflammation: Mechanistic Aspects and Applications.

Author information

1
College of Animal Science and Technology, Southwest University, Chongqing, China.
2
Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, Subtropical Institute of Animal Nutrition and Feed, South China Agricultural University, Guangzhou, Guangdong, China.
3
Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.

Abstract

Betaine is known as trimethylglycine and is widely distributed in animals, plants, and microorganisms. Betaine is known to function physiologically as an important osmoprotectant and methyl group donor. Accumulating evidence has shown that betaine has anti-inflammatory functions in numerous diseases. Mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-κB activity and NLRP3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis. Consequently, betaine has beneficial actions in several human diseases, such as obesity, diabetes, cancer, and Alzheimer's disease.

KEYWORDS:

betaine; endoplasmic reticulum; inflammation; obesity; oxidative stress

PMID:
29881379
PMCID:
PMC5976740
DOI:
10.3389/fimmu.2018.01070
[Indexed for MEDLINE]
Free PMC Article

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