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Int J Chron Obstruct Pulmon Dis. 2018 May 29;13:1767-1774. doi: 10.2147/COPD.S163472. eCollection 2018.

Acute exacerbation of COPD during pulmonary rehabilitation: outcomes and risk prediction.

Author information

1
Pulmonary Rehabilitation Unit, Pulmonary Department, Centre Hospitalier De Bligny, Briis sous Forges, France.
2
Pneumology Unit, Hôpital A. Paré, Boulogne-Billancourt, France.

Abstract

Purpose:

This study was performed to examine acute exacerbation of COPD (AECOPD) during pulmonary rehabilitation (PR) and the usefulness of multidimensional indices (MIs) to predict AECOPD at enrolment in PR.

Patients and methods:

A 4-week PR program (PRP) was implemented for 125 consecutive patients with COPD. At baseline and PRP completion, we recorded the FEV1, 6-minute walk test, peak work rate at cardiopulmonary testing, modified Medical Research Council score, and COPD Assessment Test (CAT) score. The risk of AECOPDs at baseline was assessed using the body mass index, airway obstruction, dyspnea, Exercise capacity (BODE), dyspnea, obstruction, smoking, exacerbation (DOSE), and score to predict short-term risk of COPD exacerbations (SCOPEX) MIs.

Results:

Thirty-two episodes of AECOPD occurred. The COPD status was worse in patients with than without AECOPD at baseline (lower FEV1, 6-minute walk test, and peak work rate; higher modified Medical Research Council and CAT scores). The sensitivities of the BODE, DOSE, and SCOPEX MIs to predict the occurrence of AECOPD during PRP were 78.1%, 21.9%, and 84.4%, and the specificities were 73.6%, 87.1%, and 51.6%, respectively.

Conclusion:

The BODE and SCOPEX MIs help to predict the exacerbation risk during PR.

KEYWORDS:

COPD; exacerbation; multidimensional indices; rehabilitation

PMID:
29881266
PMCID:
PMC5985797
DOI:
10.2147/COPD.S163472
[Indexed for MEDLINE]
Free PMC Article

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