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World J Gastroenterol. 2018 Jun 7;24(21):2236-2246. doi: 10.3748/wjg.v24.i21.2236.

Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells.

Author information

1
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
2
Division of Cardiology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
3
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. gzliguoxin@163.com.

Abstract

Gastric cancer (GC), with its high incidence and mortality rates, is a highly fatal cancer that is common in East Asia particularly in China. Its recurrence and metastasis are the main causes of its poor prognosis. Circulating tumor cells (CTCs) or other blood biomarkers that are released into the circulating blood stream by tumors are thought to play a crucial role in the recurrence and metastasis of gastric cancer. Therefore, the detection of CTCs and other blood biomarkers has an important clinical significance; in fact, they can help predict the prognosis, assess the staging, monitor the therapeutic effects and determine the drug susceptibility. Recent research has identified many blood biomarkers in GC, such as various serum proteins, autoantibodies against tumor associated antigens, and cell-free DNAs. The analysis of CTCs and circulating cell-free tumor DNA (ctDNA) in the peripheral blood of patients with gastric cancer is called as liquid biopsy. These blood biomarkers provide the disease status for individuals and have clinical meaning. In this review, we focus on the recent scientific advances regarding CTCs and other blood biomarkers, and discuss their origins and clinical meaning.

KEYWORDS:

Autoantibodies; Biomarker; Cell-free DNA; Circulating tumor cells; Gastric cancer

PMID:
29881233
PMCID:
PMC5989238
DOI:
10.3748/wjg.v24.i21.2236
[Indexed for MEDLINE]
Free PMC Article

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