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J Nat Prod. 2018 Jun 22;81(6):1444-1450. doi: 10.1021/acs.jnatprod.8b00175. Epub 2018 Jun 7.

Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae.

Author information

1
Natural Constituents Research Center , Korea Institute of Science and Technology (KIST) Gangneung Institute , Gangneung 25451 , Republic of Korea.
2
Herbal Medicine Research Division , Korea Institute of Oriental Medicine , Daejeon 34054 , Republic of Korea.
3
Convergence Research Center for Diagnosis, Treatment and Care System of Dementia , Korea Institute of Science and Technology , Seoul 02792 , Republic of Korea.
4
Department of Pharmaceutical Engineering , Cheongju University , Cheongju 28503 , Republic of Korea.
5
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300353 , People's Republic of China.
6
Laboratory Animal Resource Center , Korea Research Institute of Bioscience and Biotechnology , Cheongju 28116 , Republic of Korea.

Abstract

A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

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