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J Proteome Res. 2018 Aug 3;17(8):2600-2610. doi: 10.1021/acs.jproteome.8b00042. Epub 2018 Jun 28.

Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women.

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Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Technology Reference Net (XaRTA), Nutrition and Food Safety Research Institute (INSA), Faculty of Pharmacy and Food Sciences , University of Barcelona , Avinguda Joan XXIII 27-31 , Barcelona 08028 , Spain.
CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES) , Instituto de Salud Carlos III , Barcelona 08028 , Spain.
Department of Food Science , Swedish University of Agricultural Sciences , Uppsala 750 07 , Sweden.
Food and Nutrition Division, Department of Biology and Biological Engineering , Chalmers University of Technology , Göteborg 412 58 , Sweden.
Internal Medicine Department, Biomedical Institute of Malaga (IBIMA) , Regional University Hospital of Malaga (Carlos Haya Hospital) , Málaga 29010 , Spain.
Ciber Fisiopatología de la Obesidad y Nutrición , Instituto de Salud Carlos III , Madrid 28029 , Spain.
Endocrinology and Nutrition Department, Biomedical Institute of Malaga (IBIMA) , Regional University Hospital of Malaga (Virgen de la Victoria Hospital) , Málaga 29010 , Spain.


Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted 1H NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG; higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism.


NMR; hypocaloric diet; metabolically healthy obesity; metabolomics; physical activity

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