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Intern Med. 2018 Oct 15;57(20):2975-2980. doi: 10.2169/internalmedicine.0942-18. Epub 2018 Jun 6.

Legionella Pneumonia Complicated with Acquired Fanconi Syndrome.

Author information

1
Department of Nephrology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
2
Department of Respiratory Medicine, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
3
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Japan.

Abstract

Legionella pneumonia is occasionally accompanied by renal complications; however, the cause of this remains unknown. We herein report a 70-year-old Japanese man with Legionella pneumonia who presented with hyponatremia, hypophosphatemia, and hypouricemia. The levels of urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase were remarkably high, indicating severe renal tubular damage. The presence of glycosuria and aminoaciduria as well as increased fractional excretion of uric acid and decreased tubular reabsorption of phosphate indicated that the patient's condition was complicated with Fanconi syndrome. After antimicrobial therapy, the electrolyte abnormalities and renal tubular damage were completely resolved.

KEYWORDS:

Fanconi syndrome; Legionella pneumonia; aminoaciduria; rhabdomyolysis

PMID:
29877286
PMCID:
PMC6232029
DOI:
10.2169/internalmedicine.0942-18
[Indexed for MEDLINE]
Free PMC Article

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