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Intern Med. 2018 Nov 1;57(21):3135-3139. doi: 10.2169/internalmedicine.0444-17. Epub 2018 Jun 6.

The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature.

Author information

1
Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Japan.
2
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan.
3
Department of Pathology, Gunma University Hospital, Japan.
4
Department of Rheumatology and Nephrology, Japan Red Cross Maebashi Hospital, Japan.

Abstract

Nivolumab is an anti-programmed cell death-1 (PD-1) antibody that is utilized as an immune checkpoint inhibitor (ICI) for cancer therapy. We herein present the case of a 57-year-old man who developed acute kidney injury during treatment with nivolumab for lung cancer. A renal biopsy revealed acute tubulointerstitial nephritis. Immunohistochemical staining demonstrated marked infiltration of macrophages and T cells together with mild B cell infiltration. Of note, strong CD163+ M2 macrophage infiltration was observed. The cessation of nivolumab and high-dose prednisolone therapy improved the renal function of the patient. Further, we review the pertinent literature on renal-infiltrating cells in ICI-induced tubulointerstitial nephritis.

KEYWORDS:

M2 macrophage; acute tubulointerstitial nephritis; anti-PD-1 antibody; immune checkpoint inhibitor

PMID:
29877267
PMCID:
PMC6262704
DOI:
10.2169/internalmedicine.0444-17
[Indexed for MEDLINE]
Free PMC Article

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