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J Diabetes. 2018 Dec;10(12):977-983. doi: 10.1111/1753-0407.12798. Epub 2018 Jul 4.

Association between urinary tin concentration and diabetes in nationally representative sample of US adults.

Liu B1, Sun Y1, Lehmler HJ2,3, Bao W1,3,4,5,6.

Author information

1
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.
2
Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USA.
3
Environmental Health Sciences Research Center, University of Iowa, Iowa City, Iowa, USA.
4
Obesity Research and Education Initiative, University of Iowa, Iowa City, Iowa, USA.
5
Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA.
6
Center for Global and Regional Environmental Research, University of Iowa, Iowa City, Iowa, USA.

Abstract

BACKGROUND:

Animal studies indicate that chronic exposure to certain tin compounds induces pancreatic islet cell apoptosis and glucose intolerance. However, little is known about the health effects of environmental tin exposure in humans. Therefore, we evaluated the association of tin exposure with diabetes in a nationally representative sample of US adults.

METHODS:

We used data from a nationally representative population (n = 3371) in the National Health and Nutrition Examination Survey 2011-14. Diabetes (n = 605) was defined as self-reported physician's diagnosis, HbA1c ≥6.5%, fasting plasma glucose ≥126 mg/dL, or 2-h plasma glucose ≥200 mg/dL. Tin concentrations in urine samples were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) of diabetes and 95% confidence intervals (CIs).

RESULTS:

Urinary tin concentrations were higher in individuals with diabetes (weighted median 0.58 μg/L) than those without diabetes (0.39 μg/L). After adjustment for urinary creatinine and other diabetes risk factors, the OR of diabetes comparing the highest with lowest quartile of urinary tin concentrations was 1.6 (95% CI 1.0-2.6; Ptrend  = 0.02).

CONCLUSIONS:

Environmental tin exposure was positively and significantly associated with diabetes in US adults.

KEYWORDS:

US adults; diabetes; epidemiology; human health; tin exposure; 人类健康; 流行病学; 糖尿病; 美国成年人; 锡接触

PMID:
29877038
PMCID:
PMC6218306
[Available on 2019-12-01]
DOI:
10.1111/1753-0407.12798
[Indexed for MEDLINE]

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