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Adv Mater. 2018 Sep;30(37):e1707365. doi: 10.1002/adma.201707365. Epub 2018 Jun 6.

Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine.

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INSERM U1148, Laboratory for Vascular Translational Science, X. Bichat Hospital, Paris Diderot University, Paris 13 University, 75018, Paris, France.
Institut Galien, Université Paris-Sud, UMR CNRS 8612, University Paris Saclay, 92290, Chatenay Malabry, France.
Institut des Matériaux Poreux de Paris, Ecole Normale Supérieure, Ecole Supérieure de Physique et de Chimie Industrielles de Paris, FRE CNRS 2000, PSL Research University, 75005, Paris, France.


In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.


drug delivery; in vivo evaluation; metal-organic frameworks; nanomedicine; surface modification


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