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Adv Sci (Weinh). 2018 Feb 22;5(5):1700847. doi: 10.1002/advs.201700847. eCollection 2018 May.

Oxygen-Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors.

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Department of Medical Imaging Jinling Hospital School of Medicine Nanjing University Nanjing 210002 Jiangsu P. R. China.
Department of Interventional Radiology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu P. R. China.
Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei P. R. China.
State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University 210093 Nanjing P. R. China.


Oxygen (O2) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen-evolving nanoplatform is costructured to overcome this problem. It is composed of a prussian blue (PB) core and chlorin e6 (Ce6) anchored periodic mesoporous organosilica (PMO) shell (denoted as PB@PMO-Ce6). In the highly integrated nanoplatform, the PB with catalase-like activity can catalyze hydrogen peroxide to generate O2, and the Ce6 transform the O2 to generate more reactive oxygen species (ROS) upon laser irradiation for PDT. This PB@PMO-Ce6 nanoplatform presents well-defined core-shell structure, uniform diameter (105 ± 12 nm), and high biocompatibility. This study confirms that the PB@PMO-Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level (p < 0.001). In vivo, the singlet oxygen sensor green staining, tumor volume of tumor-bearing mice, and histopathological analysis demonstrate that this oxygen-evolving nanoplatform can elevate singlet oxygen to effectively inhibit tumor growth without obvious damage to major organs. The preliminary results from this study indicate the potential of biocompatible PB@PMO-Ce6 nanoplatform to elevate O2 and ROS for improving PDT efficacy.


chlorin e6; oxygen‐evolving nanoplatforms; periodic mesoporous organosilica; photodynamic therapy; prussian blue

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