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Adv Sci (Weinh). 2018 Feb 22;5(5):1700847. doi: 10.1002/advs.201700847. eCollection 2018 May.

Oxygen-Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors.

Author information

1
Department of Medical Imaging Jinling Hospital School of Medicine Nanjing University Nanjing 210002 Jiangsu P. R. China.
2
Department of Interventional Radiology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu P. R. China.
3
Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei P. R. China.
4
State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University 210093 Nanjing P. R. China.

Abstract

Oxygen (O2) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen-evolving nanoplatform is costructured to overcome this problem. It is composed of a prussian blue (PB) core and chlorin e6 (Ce6) anchored periodic mesoporous organosilica (PMO) shell (denoted as PB@PMO-Ce6). In the highly integrated nanoplatform, the PB with catalase-like activity can catalyze hydrogen peroxide to generate O2, and the Ce6 transform the O2 to generate more reactive oxygen species (ROS) upon laser irradiation for PDT. This PB@PMO-Ce6 nanoplatform presents well-defined core-shell structure, uniform diameter (105 ± 12 nm), and high biocompatibility. This study confirms that the PB@PMO-Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level (p < 0.001). In vivo, the singlet oxygen sensor green staining, tumor volume of tumor-bearing mice, and histopathological analysis demonstrate that this oxygen-evolving nanoplatform can elevate singlet oxygen to effectively inhibit tumor growth without obvious damage to major organs. The preliminary results from this study indicate the potential of biocompatible PB@PMO-Ce6 nanoplatform to elevate O2 and ROS for improving PDT efficacy.

KEYWORDS:

chlorin e6; oxygen‐evolving nanoplatforms; periodic mesoporous organosilica; photodynamic therapy; prussian blue

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