Genomic atlas of the human plasma proteome

Nature. 2018 Jun;558(7708):73-79. doi: 10.1038/s41586-018-0175-2. Epub 2018 Jun 6.

Abstract

Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL study. We identify 1,927 genetic associations with 1,478 proteins, a fourfold increase on existing knowledge, including trans associations for 1,104 proteins. To understand the consequences of perturbations in plasma protein levels, we apply an integrated approach that links genetic variation with biological pathway, disease, and drug databases. We show that protein quantitative trait loci overlap with gene expression quantitative trait loci, as well as with disease-associated loci, and find evidence that protein biomarkers have causal roles in disease using Mendelian randomization analysis. By linking genetic factors to diseases via specific proteins, our analyses highlight potential therapeutic targets, opportunities for matching existing drugs with new disease indications, and potential safety concerns for drugs under development.

MeSH terms

  • Blood Proteins / genetics*
  • Female
  • Genomics*
  • Hepatocyte Growth Factor / genetics
  • Humans
  • Inflammatory Bowel Diseases / genetics
  • Male
  • Mutation, Missense / genetics
  • Myeloblastin / genetics
  • Positive Regulatory Domain I-Binding Factor 1 / genetics
  • Proteome / genetics*
  • Proto-Oncogene Proteins / genetics
  • Quantitative Trait Loci / genetics
  • Vasculitis / genetics
  • alpha 1-Antitrypsin / genetics

Substances

  • Blood Proteins
  • Proteome
  • Proto-Oncogene Proteins
  • SERPINA1 protein, human
  • alpha 1-Antitrypsin
  • macrophage stimulating protein
  • PRDM1 protein, human
  • Hepatocyte Growth Factor
  • Positive Regulatory Domain I-Binding Factor 1
  • Myeloblastin