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Elife. 2018 Jun 6;7. pii: e33891. doi: 10.7554/eLife.33891.

Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals.

Yao JD1, Sanes DH1,2,3,4.

Author information

1
Center for Neural Science, New York University, New York, United States.
2
Department of Psychology, New York University, New York, United States.
3
Department of Biology, New York University, New York, United States.
4
Neuroscience Institute, NYU Langone Medical Center, New York, United States.

Abstract

Sensory deprivation during development induces lifelong changes to central nervous system function that are associated with perceptual impairments. However, the relationship between neural and behavioral deficits is uncertain due to a lack of simultaneous measurements during task performance. Therefore, we telemetrically recorded from auditory cortex neurons in gerbils reared with developmental conductive hearing loss as they performed an auditory task in which rapid fluctuations in amplitude are detected. These data were compared to a measure of auditory brainstem temporal processing from each animal. We found that developmental HL diminished behavioral performance, but did not alter brainstem temporal processing. However, the simultaneous assessment of neural and behavioral processing revealed that perceptual deficits were associated with a degraded cortical population code that could be explained by greater trial-to-trial response variability. Our findings suggest that the perceptual limitations that attend early hearing loss are best explained by an encoding deficit in auditory cortex.

KEYWORDS:

brainstem; cortex; development; gerbil; hearing loss; neuroscience; temporal processing

PMID:
29873632
PMCID:
PMC6005681
DOI:
10.7554/eLife.33891
[Indexed for MEDLINE]
Free PMC Article

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