eIF2α phosphorylation: A hallmark of immunogenic cell death

Lucillia Bezu; Allan Sauvat; Juliette Humeau; Marion Leduc; Oliver Kepp; Guido Kroemer

doi:10.1080/2162402X.2018.1431089

eIF2α phosphorylation: A hallmark of immunogenic cell death

Oncoimmunology. 2018 Feb 14;7(6):e1431089. doi: 10.1080/2162402X.2018.1431089. eCollection 2018.

Authors

Lucillia Bezu^{1

2

3

4

5

6}, Allan Sauvat^{2

3

4

5

6}, Juliette Humeau^{1

2

3

4

5

6}, Marion Leduc^{2

3

4

5

6}, Oliver Kepp^{2

3

4

5

6}, Guido Kroemer^{2

3

4

5

6

7

8

9}

Affiliations

¹ Faculty of Medicine, University of Paris Sud, Kremlin-Bicêtre, France.
² Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus; Villejuif, France.
³ Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers; Paris, France.
⁴ Institut National de la Santé et de la Recherche Médicale, U1138, Equipe labellisée Ligue Nationale Contre le Cancer, Villejuif, France.
⁵ Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
⁶ Université Pierre et Marie Curie, Paris, France.
⁷ Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France.
⁸ Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP; Paris, France.
⁹ Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

Abstract

Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

Keywords: ER stress; anthracyclines; cancer; chemotherapy; unfolded protein response.

Publication types

Research Support, Non-U.S. Gov't