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BMJ Case Rep. 2018 Jun 5;2018. pii: bcr-2018-224722. doi: 10.1136/bcr-2018-224722.

Severe bone marrow suppression due to methotrexate toxicity following aceclofenac-induced acute kidney injury.

Author information

1
Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India.
2
Medical Oncology, Baby Memorial Hospital, Calicut, Kerala, India.
3
Nephrology, Baby Memorial Hospital, Calicut, Kerala, India.
4
Medical Gastroenterology, Baby Memorial Hospital, Calicut, Kerala, India.

Abstract

Methotrexate is one of the most commonly used drugs in autoimmune disorders like rheumatoid arthritis. Gastrointestinal symptoms like nausea and stomatitis, skin rashes, alopecia, central nervous system symptoms like headache and confusion, hepatotoxicity and myelosuppression are some of the adverse effects. However, low oral doses on a weekly basis seldom show any signs of toxicity. Leucovorin or folinic acid is given along with methotrexate as rescue to reduce the toxic effects like bone marrow suppression. Non-steroidal anti-inflammatory drugs, like aceclofenac, are also used in chronic inflammatory conditions like rheumatoid arthritis and osteoarthritis. Nephrotoxicity is one of the adverse effects of both methotrexate and non-steroidal anti-inflammatory drugs; and its combined administration should be done with caution. This is a case of an elderly woman, a known case of rheumatoid arthritis, who presented in severe bone marrow suppression due to methotrexate toxicity following aceclofenac-induced acute kidney injury.

KEYWORDS:

acute renal failure; rheumatoid arthritis

PMID:
29871962
DOI:
10.1136/bcr-2018-224722

Conflict of interest statement

Competing interests: None declared.

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