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Int J Infect Dis. 2018 Aug;73:49-51. doi: 10.1016/j.ijid.2018.05.016. Epub 2018 Jun 2.

Decompressive craniectomy as salvage treatment in herpes simplex encephalitis: Two case reports.

Author information

1
Department of Neuroinfections and Intensive Care Medicine, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia. Electronic address: mkusulja@kusulja.com.
2
Department of Neuroinfections and Intensive Care Medicine, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia.

Abstract

Herpes simplex encephalitis is a rare disease with significant morbidity and mortality, although targeted therapy is widely available. This report presents two cases of herpes simplex encephalitis in previously healthy, young adults treated with acyclovir, who developed severe brain edema. Decompressive craniectomy prevented imminent brain herniation and a fatal outcome in both of these patients.

KEYWORDS:

Brain edema; Decompressive craniectomy; Encephalitis; Herpes simplex virus; Intracranial hypertension

PMID:
29870796
DOI:
10.1016/j.ijid.2018.05.016
[Indexed for MEDLINE]
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