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Drug Deliv. 2018 Nov;25(1):1362-1371. doi: 10.1080/10717544.2018.1477865.

Development of a docetaxel micellar formulation using poly(ethylene glycol)-polylactide-poly(ethylene glycol) (PEG-PLA-PEG) with successful reconstitution for tumor targeted drug delivery.

Author information

1
a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
2
b College of Pharmacy & Institute of Pharmaceutical Science and Technology , Hanyang University , Ansan , Republic of Korea.
3
c Department of Biotechnology , The Catholic University of Korea , Bucheon , Republic of Korea.
4
d School of Pharmacy , SungKyunKwan University , Suwon City , Republic of Korea.
5
e College of Pharmacy , Dongguk University-Seoul , Goyang , Republic of Korea.
6
f College of Pharmacy , Catholic University of Daegu , Gyeongsan-si , Republic of Korea.

Abstract

Docetaxel (DTX)-loaded polymeric micelles (DTBM) were formulated using the triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol) (PEG-PLA-PEG), to comprehensively study their pharmaceutical application as anticancer nanomedicine. DTBM showed a stable formulation of anticancer nanomedicine that could be reconstituted after lyophilization (DTBM-R) in the presence of PEG 2000 and D-mannitol (Man) as surfactant and protectant, respectively. DTBM-R showed a particle size less than 150 nm and greater than 90% of DTX recovery after reconstitution. The robustly formed micelles might minimize systemic toxicity due to their sustained drug release and also maximize antitumor efficacy through increased accumulation and release of DTX from the micelles. From the pharmaceutical development point of view, DTBM-R showing successful reconstitution could be considered as a potent nanomedicine for tumor treatment.

KEYWORDS:

Nanomedicine; cancer; lyophilization; polymeric micelle; reconstitution

PMID:
29869563
PMCID:
PMC6060706
DOI:
10.1080/10717544.2018.1477865
[Indexed for MEDLINE]
Free PMC Article

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