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Biofouling. 2018 May;34(5):579-593. doi: 10.1080/08927014.2018.1473387. Epub 2018 Jun 5.

Inhibitory effect of α-mangostin on Acinetobacter baumannii biofilms - an in vitro study.

Author information

1
a Department of Biotechnology , Alagappa University , Karaikudi , India.

Abstract

The present study was designed to investigate the anti-biofilm potential of alpha-mangostin (α-MG) against Acinetobacter baumannii (AB). The biofilm inhibitory concentration (BIC) of α-MG against AB was found to be 2 μg ml-1. α-MG (0.5, 1 and 2 μg ml-1) exhibited non-bactericidal concentration-dependent anti-biofilm activities against AB. However, α-MG failed to disintegrate the mature biofilms of AB even at a 10-fold increased concentration from its BIC. Results from qRT-PCR and in vitro bioassays further demonstrated that α-MG downregulated the expression of bfmR, pgaA, pgaC, csuA/B, ompA, bap, katE, and sodB genes, which correspondingly affects biofilm formation and its associated virulence traits. The present study suggests that α-MG exerts its anti-biofilm property by interrupting initial biofilm formation and the cell-to-cell signaling mechanism of AB. Additional studies are required to understand the mode of action responsible for the anti-biofilm property.

KEYWORDS:

Acinetobacter baumannii; alpha-mangostin; biofilm; catalase; quorum sensing; superoxide dismutase

PMID:
29869541
DOI:
10.1080/08927014.2018.1473387
[Indexed for MEDLINE]

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