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Clin Transl Oncol. 2018 Dec;20(12):1502-1521. doi: 10.1007/s12094-018-1896-2. Epub 2018 Jun 4.

New physical approaches to treat cancer stem cells: a review.

Author information

1
Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Junction of Shahid Hemmat and Chamran Expressway, Tehran, Iran.
2
Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Junction of Shahid Hemmat and Chamran Expressway, Tehran, Iran. srmahdavi@hotmail.com.
3
Department of Medical Physics and Radiation Biology Research Center, Iran University of Medical Sciences, Junction of Shahid Hemmat and Chamran Expressway, Tehran, Iran. srmahdavi@hotmail.com.
4
Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Junction of Shahid Hemmat and Chamran Expressway, Tehran, Iran. hamid_rbp@yahoo.com.

Abstract

Cancer stem cells (CSCs) have been identified as the main center of tumor therapeutic resistance. They are highly resistant against current cancer therapy approaches particularly radiation therapy (RT). Recently, a wide spectrum of physical methods has been proposed to treat CSCs, including high energetic particles, hyperthermia (HT), nanoparticles (NPs) and combination of these approaches. In this review article, the importance and benefits of the physical CSCs therapy methods such as nanomaterial-based heat treatments and particle therapy will be highlighted.

KEYWORDS:

Cancer stem cells; Hyperthermia; Nanoparticles; Particle beams; Radiation resistance

PMID:
29869042
DOI:
10.1007/s12094-018-1896-2
[Indexed for MEDLINE]

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