Format

Send to

Choose Destination
Front Psychiatry. 2018 May 8;9:185. doi: 10.3389/fpsyt.2018.00185. eCollection 2018.

Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls.

Author information

1
Laboratory of Hormone Measurement, Department of Physiology, Federal University of Rio Grande do Norte, Natal, Brazil.
2
Postgraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, Brazil.
3
Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
4
Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, Natal, Brazil.
5
Department of Clinical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.
6
National Institute of Science and Technology in Translational Medicine, Natal, Brazil.
7
Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil.

Abstract

Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. The aim of this study was to explore the effect of ayahuasca on plasma cortisol and awakening salivary cortisol response, in the same group of treatment-resistant patients (MD) and in healthy volunteers (C). Subjects received a single dose of ayahuasca or placebo (dosing session), and both plasma and awakening salivary cortisol response were measured at baseline (before dosing session) and 48 h after the dosing session. Baseline assessment (D0) showed blunted awakening salivary cortisol response and hypocortisolemia in patients, with respect to healthy controls. Salivary cortisol was also measured during dosing session, and we observed higher increases for both C and MD that ingested ayahuasca than placebo. After 48 h from the dosing session with ayahuasca, patients' awakening salivary cortisol response is similar to the ones detected in controls. No significant changes in plasma cortisol levels were observed 48 h after the sessions. Therefore, these findings point to new evidence on the modulation of salivary cortisol levels as a result of an ayahuasca session, both in healthy and depressive volunteers. Considering that cortisol acts in regulation of distinct physiological pathways, emotional and cognitive processes, it is assumed to be critically involved to the etiology of depression and its regulation seems to be important for the treatment and remission of major depression, ayahuasca use as antidepressant should be further investigated. Moreover, this study highlights the importance of psychedelics in the treatment of human mental disorders.

KEYWORDS:

awakening salivary cortisol; ayahuasca; hypocortisolemia; plasma cortisol; treatment-resistant depression

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center