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Front Pharmacol. 2018 May 17;9:507. doi: 10.3389/fphar.2018.00507. eCollection 2018.

Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations.

Author information

1
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
2
Department of Biology, Carlow University, Pittsburgh, PA, United States.
3
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States.
4
Department of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, PA, United States.
5
McGowan Institute for Regenerative Medicine, Pittsburgh, PA, United States.
6
Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, United States.

Abstract

Tissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat grafting (AFG) is not a reliable option. This review focuses on the latest therapeutic strategies for the treatment of adipose tissue defects using biomolecule formulations and delivery, and specifically engineered biomaterials. Additionally, the clinical need for reliable off-the-shelf therapies, animal models, and challenges facing current technologies are discussed.

KEYWORDS:

adipogenic factors; adipose tissue restoration; adipose-derived stem cells; microspheres; soft tissue defects

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