Format

Send to

Choose Destination
Front Neuroanat. 2018 May 15;12:40. doi: 10.3389/fnana.2018.00040. eCollection 2018.

Shaping Synapses by the Neural Extracellular Matrix.

Author information

1
Molecular Neuroplasticity German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
2
Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.
3
Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.

Abstract

Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a tetrapartite synapse. Here we outline the major mechanisms driving: (i) synaptogenesis by secreted extracellular scaffolding molecules, like thrombospondins (TSPs), neuronal pentraxins (NPs) and cerebellins, which respectively promote presynaptic, postsynaptic differentiation or both; (ii) maturation of synapses via reelin and integrin ligands-mediated signaling; and (iii) regulation of synaptic plasticity by ECM-dependent control of induction and consolidation of new synaptic configurations. Particularly, we focused on potential importance of activity-dependent concerted activation of multiple extracellular proteases, such as ADAMTS4/5/15, MMP9 and neurotrypsin, for permissive and instructive events in synaptic remodeling through localized degradation of perisynaptic ECM and generation of proteolytic fragments as inducers of synaptic plasticity.

KEYWORDS:

disease; perineuronal net; proteolysis; synaptic plasticity; synaptogenesis

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center