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Expert Opin Drug Metab Toxicol. 2018 Jul;14(7):679-692. doi: 10.1080/17425255.2018.1484450. Epub 2018 Jun 11.

The potential effects of Ocimum basilicum on health: a review of pharmacological and toxicological studies.

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a Department of Biomolecular Sciences , University of Urbino Carlo Bo , Urbino (PU) , Italy.
b Institute of Food Science & Nutrition, Faculty of Agricultural Sciences and Technology , Bahauddin Zakariya University , Multan , Punjab , Pakistan.
c Department for Life Quality Studies , Alma Mater Studiorum-University of Bologna , Rimini (RN) , Italy.


Basil (Ocimum basilicum L., OB) is a plant world widely used as a spice and a typical ingredient of the healthy Mediterranean diet. In traditional medicine, OB is indicated for many maladies and conditions; OB-containing nutritional supplements are increasingly sold. Conversely, safety concerns have been raised about the promutagens and procarcinogens alkenylbenzenes contained in OB. Areas covered: A critical review of the current status of OB as a nutraceutical, the pharmacology of its bioactive components, the rationale for its indications, and its safety. Expert opinion: Due to the polyphenolic and flavonoidic content, OB can be considered as an important ingredient in healthy diets; OB preparations may be effective as chemopreventive agents or adjunctive therapy in the treatment of different clinical conditions. From a toxicological perspective, since the tumorigenic potential of alkenylbenzenes is counteracted by other OB constituents such as nevadensin, it can be concluded that OB consumption in food and preparations is safe. The only concern relates to OB essential oils: in this case, a concentration limit for alkenylbenzenes should be precautionary defined, and the use of plant chemotypes with no or low levels of these alkylbenzenes for the preparation of essential oils should be made compulsory.


Alkenylbenzenes; Ocimum basilicum; estragole; genotoxicity; health-promoting effects

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