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Diseases. 2018 Jun 2;6(2). pii: E47. doi: 10.3390/diseases6020047.

Psoriasis and Microbiota: A Systematic Review.

Author information

1
Dermatology Department, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, Anderlecht, 1070 Brussels, Belgium. farida.benhadou@erasme.ulb.ac.be.
2
Dermatology Department, Sir Paul Boffa Hospital, 1491 Floriana, Malta. dillon.mintoff@gov.mt.
3
Medecine Faculty, Université Libre de Bruxelles, 1070 Brussels, Belgium. bschnebe@ulb.ac.be.
4
Dermatology Department, Erasmus Medical Center, 3000 Rotterdam, The Netherlands. h.thio@erasmusmc.nl.

Abstract

BACKGROUND:

Recent advances have highlighted the crucial role of microbiota in the pathophysiology of chronic inflammatory diseases as well as its impact on the efficacy of therapeutic agents. Psoriasis is a chronic, multifactorial inflammatory skin disorder, which has a microbiota distinct from healthy, unaffected skin.

AIM:

Through an extensive review of the literature, we aim to discuss the skin and gut microbiota and redefine their role in the pathogenesis of psoriasis.

CONCLUSIONS:

Unfortunately, the direct link between the skin microbiota and the pathogenesis of psoriasis remains to be clearly established. Apart from improving the course of psoriasis, selective modulation of the microbiota may increase the efficacy of medical treatments as well as attenuate their side effects.

KEYWORDS:

microbiota; prebiotics; probiotics; psoriasis

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