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Nutrients. 2018 Jun 2;10(6). pii: E713. doi: 10.3390/nu10060713.

Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Author information

1
Department of Nutrition, Faculty of Public Health, Mahidol University, Bangkok 10400, Thailand. abnutrition@yahoo.com.
2
Department of Nutrition, Faculty of Public Health, Mahidol University, Bangkok 10400, Thailand. supathra.lil@mahidol.ac.th.
3
Institute of Nutrition, Mahidol University, Nakhonpathom 73170, Thailand. siriporn.tun@mahidol.ac.th.
4
Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. nednapis.tir@mahidol.ac.th.
5
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. surat_komindr@yahoo.com.

Abstract

Ferulic acid is the most abundant phenolic compound found in vegetables and cereal grains. In vitro and animal studies have shown ferulic acid has anti-hyperlipidemic, anti-oxidative, and anti-inflammatory effects. The objective of this study is to investigate the effects of ferulic acid supplementation on lipid profiles, oxidative stress, and inflammatory status in hyperlipidemia. The study design is a randomized, double-blind, placebo-controlled trial. Subjects with hyperlipidemia were randomly divided into two groups. The treatment group (n = 24) was given ferulic acid (1000 mg daily) and the control group (n = 24) was provided with a placebo for six weeks. Lipid profiles, biomarkers of oxidative stress and inflammation were assessed before and after the intervention. Ferulic acid supplementation demonstrated a statistically significant decrease in total cholesterol (8.1%; p = 0.001), LDL-C (9.3%; p < 0.001), triglyceride (12.1%; p = 0.049), and increased HDL-C (4.3%; p = 0.045) compared with the placebo. Ferulic acid also significantly decreased the oxidative stress biomarker, MDA (24.5%; p < 0.001). Moreover, oxidized LDL-C was significantly decreased in the ferulic acid group (7.1%; p = 0.002) compared with the placebo group. In addition, ferulic acid supplementation demonstrated a statistically significant reduction in the inflammatory markers hs-CRP (32.66%; p < 0.001) and TNF-α (13.06%; p < 0.001). These data indicate ferulic acid supplementation can improve lipid profiles and oxidative stress, oxidized LDL-C, and inflammation in hyperlipidemic subjects. Therefore, ferulic acid has the potential to reduce cardiovascular disease risk factors.

KEYWORDS:

anti-inflammation; anti-oxidant; ferulic acid; lipid profiles; phenolic compound

PMID:
29865227
PMCID:
PMC6024557
DOI:
10.3390/nu10060713
[Indexed for MEDLINE]
Free PMC Article

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