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Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 30;86:175-179. doi: 10.1016/j.pnpbp.2018.05.022. Epub 2018 Jun 1.

Infertility treatments during pregnancy and the risk of autism spectrum disorder in the offspring.

Author information

1
Child Development, Medical Division, Maccabi Healthcare Services, Tel Aviv, Israel; Maccabi Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.
2
Maccabi Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.
3
OBGYN Maccabi Health Care, Israel.
4
Department of Psychiatry, Department of Preventive Medicine, Seaver Autism Center for Research and Treatment, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, United States.
5
The Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
6
Department of Community Mental Health, University of Haifa, Haifa 31905, Israel. Electronic address: slevine@univ.haifa.ac.il.

Abstract

We aimed to examine the effects of infertility treatments on the risk of Autism Spectrum Disorder (ASD). Data were from a representative national registry on 110,093 male live births in Israel (born: 1999-2008; and ASD: 975, 0.9%). Infertility treatments included In Vitro Fertilization (IVF), and five hormone treatments. Relative risk (RR) was estimated with multivariable logistic models. Results showed that IVF treatment compared with spontaneous conception was not statistically significantly associated with the risk of ASD. Only progesterone hormone treatment was associated with a statistically significant (p < .05) increased risk of ASD (RR = 1.51, 95% CI 1.22, 1.86) compared to the group with no progesterone treatment. In conclusion, progesterone exposure during the critical period of fetal life elevated the risk of ASD, possibly reflecting epigenetic modification.

KEYWORDS:

Autism Spectrum disorders; Epidemiology; Hormone; Infertility

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