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ACS Chem Neurosci. 2018 Oct 17;9(10):2304-2306. doi: 10.1021/acschemneuro.8b00237. Epub 2018 Jun 4.

Psychedelics and Personality.

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ICEERS Foundation (International Center for Ethnobotanical Education, Research and Services) , 08015 Barcelona , Spain.
Department of Neurosciences and Behavior, Ribeirão Preto Medical School , University of São Paulo , 3900 Ribeirão Preto , Brazil.
National Institute of Science and Technology - Translational Medicine, 05508-901 São Paulo , Brazil.


In the past decade, an increasing number of clinical trials are reporting evidence that psychedelics or serotonergic hallucinogens (such as lysergic acid diethylamide, psilocybin, and ayahuasca/dimethyltryptamine) could be effective in the treatment of mood, anxiety, and substance use disorders. The mechanisms responsible for these effects are not fully understood but seem to involve changes in bran dynamics in areas rich in serotonergic 5-HT2A receptors and in personality. In the present text, we present a brief and critical overview of the current research in this field, pointing out both promises and limitations of these studies.


Psychedelics; anxiety; hallucinogens; mood; personality; substance abuse

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