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Int J Tuberc Lung Dis. 2018 Jun 1;22(6):695-703. doi: 10.5588/ijtld.17.0433.

Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital.

Author information

1
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan Society for the Promotion of Science, Tokyo.
2
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo.
3
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Department of Pulmonary Medicine, Eiju General Hospital, Tokyo.
4
Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan.

Abstract

BACKGROUND:

Little is known about the clinical characteristics and health-related quality of life (HQOL) of elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease.

OBJECTIVES:

To evaluate HQOL using the 36-Item Short-Form Health Survey and St George's Respiratory Questionnaire (SGRQ) and to investigate the predictors of HQOL changes among elderly patients with pMAC disease.

METHODS:

This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 and July 2015 and included 84 patients with pMAC disease aged 75 years who had completed the HQOL questionnaire and 48 patients with pMAC disease who had been followed up and completed the HQOL questionnaire in cross-sectional and longitudinal analyses, respectively.

RESULTS:

In cross-sectional analyses, elderly patients with pMAC disease had significantly lower role-physical, general health, vitality, social functioning, role-emotional and role/social component scores than the general Japanese elderly population. Analysis of covariance revealed that patients with cavitary lesions had significantly worse physical functioning and SGRQ scores (P < 0.05). Longitudinal analysis showed that under-treatment, short duration of disease and positive sputum smear at baseline were predictors of worse HQOL at 12 months.

CONCLUSIONS:

Elderly patients with pMAC disease have reduced HQOL. Further large studies on HQOL are required to refine the use of this parameter in the treatment of these patients.

PMID:
29862956
DOI:
10.5588/ijtld.17.0433

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