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Acta Ophthalmol. 2019 Feb;97(1):e97-e102. doi: 10.1111/aos.13830. Epub 2018 Jun 4.

Comparative assessment of intraocular inflammation following standard or heavy silicone oil tamponade: a prospective study.

Author information

1
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
2
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health - Section of Legal Medicine, University of Brescia, Brescia, Italy.
3
Department of Ophthalmology, University of Ferrara, Ferrara, Italy.
4
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
5
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

Abstract

PURPOSE:

To evaluate the inflammation associated with the use of standard silicone oil (polydimethylsiloxane; PDMS) and heavy silicone oil (HSO) Densiron-68™ in patients undergoing vitrectomy for retinal detachment.

MATERIALS AND METHODS:

A prospective study was performed involving 35 patients scheduled to undergo vitrectomy for retinal detachment. Patients received PDMS or Densiron-68™ HSO according to superior or inferior retinal localization of the tears, respectively. For assessing the inflammation, prostaglandin E2 (PGE2 ) and interleukin-1α (IL-1α) levels were evaluated in the aqueous.

RESULTS:

Thirty-five eyes of 35 patients completed the study: 20 eyes received HSO, and 15 eyes received PDMS. The mean aqueous PGE2 level was significantly higher in HSO patients than in PDMS patients (869.16 ± 242.83 pg/ml versus 369.38 ± 209.7 pg/ml, respectively; p < 0.0001). The mean aqueous IL-1α level was also significantly higher in HSO patients than in PDMS patients (81.40 ± 36.9 pg/ml versus 40.8 ± 32.5 pg/ml, respectively; p = 0.002). In HSO, a moderate positive correlation between the endotamponade duration and both PGE2 (r = 0.44; p = 0.05) and IL-1α (r = 0.48; p = 0.033) levels was observed. In PDMS, a strong positive correlation between the endotamponade duration and both PGE2 (r = 0.89; p < 0.0001) and IL-1α (r = 0.68; p = 0.006) levels was observed.

CONCLUSION:

Although both HSO and PDMS yielded favourable success rates in the surgical treatment of complicated retinal detachments, HSO triggered a more severe inflammatory reaction, in a time-dependent manner.

KEYWORDS:

heavy silicone oil; inflammation; retinal detachment; standard silicone oil; vitrectomy

PMID:
29862656
DOI:
10.1111/aos.13830
[Indexed for MEDLINE]

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