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Environ Sci Pollut Res Int. 2018 Jul;25(21):20550-20561. doi: 10.1007/s11356-018-2367-6. Epub 2018 Jun 3.

Phthalate exposure as a risk factor for hypertension.

Lu X1, Xu X1,2, Lin Y3,4, Zhang Y1,5, Huo X6,7.

Author information

1
Laboratory of Environmental Medicine and Developmental Toxicology and Guangdong Provincial Key Laboratory of Infectious Diseases, Shantou University Medical College, Shantou, 515041, Guangdong, China.
2
Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, Guangdong, China.
3
Tabor Academy, Marion, MA, USA.
4
Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 511486, Guangdong, China.
5
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
6
Laboratory of Environmental Medicine and Developmental Toxicology and Guangdong Provincial Key Laboratory of Infectious Diseases, Shantou University Medical College, Shantou, 515041, Guangdong, China. xhuo@jnu.edu.cn.
7
Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 511486, Guangdong, China. xhuo@jnu.edu.cn.

Abstract

Phthalates are ubiquitous in environment. Hypertension is a major risk factor for cardiovascular diseases. Phthalate exposure is associated with hypertension in multiple studies. This review aims to summarize the scientific literature on associations between phthalate exposure and hypertension and discuss the mechanisms in the relationship. We identified and reviewed original articles published to March 2018, using PubMed and Web of Science to search the terms "phthalate(s)," "phthalic acid," "blood pressure," "high blood pressure," "hypertension," "prehypertension," and "cardiovascular disease." Findings were summarized based on the relevance to the themes, including presentation of main phthalates and their major metabolites as well as associations of phthalate exposure with blood pressure in epidemiological and experimental studies. We identified ten population-based investigations and five toxicological experiments. Epidemiological data underscored a possible correlation between phthalate exposure and hypertension in adults, whereas individual study in children stands on the opposite. Experimental studies mainly targeted the increasing effect of phthalates on blood pressure. This review suggested some underlying mechanisms of phthalate-associated hypertension. Considering the current evidence, phthalate might be risk factors of hypertension. However, the effect of phthalate exposure in early life on blood pressure in later life or adulthood is still unclear. Well-designed longitudinal and molecular mechanism studies are indispensable.

KEYWORDS:

Blood pressure; Cardiovascular disease; Hypertension; Phthalates; Risk factor

PMID:
29862479
DOI:
10.1007/s11356-018-2367-6
[Indexed for MEDLINE]

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