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J Curr Glaucoma Pract. 2018 Jan-Apr;12(1):29-35. doi: 10.5005/jp-journals-10028-1240. Epub 2018 Mar 1.

Association of Diopsys® Short-duration Transient Visual Evoked Potential Latency with Visual Field Progression in Chronic Glaucoma.

Author information

1
Optometrist, Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, Texas, USA.
2
Director, Professor and Consultant, Department of Ophthalmology, CLI Eyes of Africa Clinic and Surgery Center, Malawi, Africa; WESMDPA Baptist Medical Center Glaucoma Service, San Antonio, Texas; Department of Biomedical Engineering, University of Texas San Antonio, San Antonio, Texas; Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, Texas, USA.

Abstract

Aim:

To determine the association of Diopsys® NOVA-LX amplitude and latency abnormality scores with perimetric staging of chronic glaucoma, and to explore potential single-visit short-duration transient visual evoked potential (SD-tVEP) trend detection ability utilizing Humphrey 30-2 field progression data.

Materials and methods:

Setting: Glaucoma subspecialty clinic. Participants: Treated adult chronic glaucoma patients undergoing SD-tVEP evaluation. Main outcome measures: (1) Proportion of eyes designated as suspect or abnormal by the NOVA-LX multifactorial algorithm were determined as a function of glaucoma severity using the most recent Humphrey visual field analyzer (HVFA) 30-2 field. (2) Association between long-term HVFA-guided progression analysis (GPA) annual slopes and SD-tVEP abnormality was assessed to determine whether a single VEP test might help to identify eyes more prone to progressive visual field (VF) loss.

Results:

One hundred and thirty-three eyes of 84 patients (mean age 68 years) were analyzed. The SD-tVEP abnormality increased proportionately with severity of VF loss under high-contrast (Hc) test conditions for both latency (p = 0.001) and amplitude (p < 0.01). The HVFA progression analysis printouts existed for 91 eyes (mean 12.3 fields per eye/range 5-18). Nearly three-quarters (72.5%) of eyes with mean annual HVFA progression >0.7 dB/year (n = 29) had single-visit VEP latency abnormalities. Fewer than half (46.7%) of the remainder (n = 62) showed latency abnormality. Mean progression for eyes with abnormal vs normal VEP latency was -0.87 ± 0.3 dB/year vs -0.32 ± 0.4 dB/year.

Conclusion:

Diopsys NOVA-LX Hc latency abnormality shows strong association with VF loss among a diverse population of clinical patients undergoing active treatment for chronic glaucoma, and appears likely to afford clinically useful trend-detecting test.

Clinical significance:

The SD-tVEP has the potential to serve as a single-visit clinical indicator to identify glaucoma patients at high risk for VF progression.How to cite this article: Trevino R, Sponsel WE, Majcher CE, Allen J, Rabin J. Association of Diopsys® Short-duration Transient Visual Evoked Potential Latency with Visual Field Progression in Chronic Glaucoma. J Curr Glaucoma Pract 2018;12(1):29-35.

KEYWORDS:

Cohort study; Electrophysiology; Glaucoma; Perimetry; Visual evoked potential.

Conflict of interest statement

Source of support: Nil Conflict of interest: Professor Sponsel is a consultant for Diopsys.

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