Zinc Oxide Nanoparticles Induced Oxidative DNA Damage, Inflammation and Apoptosis in Rat's Brain after Oral Exposure

Hala Attia; Howaida Nounou; Manal Shalaby

doi:10.3390/toxics6020029

Zinc Oxide Nanoparticles Induced Oxidative DNA Damage, Inflammation and Apoptosis in Rat's Brain after Oral Exposure

Toxics. 2018 May 26;6(2):29. doi: 10.3390/toxics6020029.

Authors

Hala Attia^{1

2}, Howaida Nounou³, Manal Shalaby⁴

Affiliations

¹ Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia. hsalem@ksu.edu.sa.
² Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. hsalem@ksu.edu.sa.
³ Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria 21111, Egypt. howaidanounou@outlook.com.
⁴ Department of Medical Biotechnology, Institute of Genetic Engineering City of Scientific Research and biotechnological applications, Borg El Arab, Alexandria 21111, Egypt. manalshalaby2870@yahoo.com.

Abstract

Growing evidences demonstrated that zinc oxide nanoparticles (ZnONPs) could reach the brain after oral ingestion; however, the "neurotoxicity of" ZnONPs after oral exposure has not been fully investigated. This study aimed to explore the "neurotoxicity of" ZnONPs (.

Keywords: DNA fragmentation; Fas; ZnONPs; brain; caspase-3; heat shock protein-70; interleukin-1β; oxidative stress.