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Ann Allergy Asthma Immunol. 2018 Aug;121(2):211-217.e3. doi: 10.1016/j.anai.2018.05.024. Epub 2018 Jun 1.

Bedroom exposure to airborne allergens in the Chicago area using a patient-operated sampling device.

Author information

1
Inspirotec Inc, Chicago, Illinois. Electronic address: jgordon@inspirotec.com.
2
Kenilworth Medical Allergy & Immunology, Kenilworth, Illinois.
3
Associated Allergy and Asthma Specialists Ltd, Chicago, Illinois.
4
Private Practice, Chicago, Illinois.
5
Allergy & Asthma Specialists, Munster, Indiana.
6
Inspirotec Inc, Chicago, Illinois.

Abstract

BACKGROUND:

In current practice, allergens in vacuum-collected dust are used as surrogates for inhalable allergens. We developed an air-sampling device that can be used by patients for direct measurement of airborne allergen concentrations in their own homes.

OBJECTIVE:

To demonstrate the use of this device to establish allergen concentration reference ranges in a target population and to evaluate associations between patient-reported information and measured allergen concentrations.

METHODS:

Patients from 5 allergist's practices in the Chicagoland region were provided with instructions, questionnaires, informed consent forms, and samplers to run for 5 days in their bedrooms. Samples were collected from cartridges and assayed by multiplex immunoassays for 12 common household allergens and enzyme-linked immunosorbent assay for ragweed.

RESULTS:

Unique allergen profiles were obtained for 102 patient homes. Samples with allergen concentrations above the limit of detection were as follows: total dust mite, 28%; cat, 61%; dog, 64%; mouse, 12%; rat, 0%; cockroach, 4%; Alternaria, 6%; Aspergillus, 21%; birch pollen 1%; grass, 8%; and ragweed, 5%. Of those, 75 completed questionnaires, providing meta-data for further analysis. Pet allergens correlated significantly with number of pets owned. Humidity correlated with dust mite allergens, open windows with Alternaria and mouse allergens, and high-efficiency particulate air filter use with reduced levels of several allergens. Many other variables showed no significant correlations.

CONCLUSION:

The combination of ease of use, high air-sampling rate, and sensitive immunoassays permitted the measurement of airborne allergen concentrations in homes and establishment of reference ranges. Patient-reported information permitted identification of factors that could relate to allergen concentrations and suggested remedial measures.

PMID:
29860049
DOI:
10.1016/j.anai.2018.05.024
[Indexed for MEDLINE]

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