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Chem Asian J. 2018 Jun 2. doi: 10.1002/asia.201800682. [Epub ahead of print]

Efficient Synthesis of Five Types of Heterocyclic Compounds via Intramolecular Elimination Using Ultrasound-Static Heating Technique.

Author information

1
Key Laboratory of Marine Drugs, Chinese, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China.
2
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, P. R. China.
3
Institute of Cerebrovascular Diseases, Affiliated Hospital of Qingdao University Medical College, Qingdao, 266500, P. R. China.

Abstract

An experimental technique, ultrasound-static heating, has been developed for the efficient synthesis of heterocyclic compounds. The technique involves ultrasonic irradiation and static heating processes. First, the ultrasonic irradiation process is performed to form an intermediate of the heterocyclic compound under mild conditions and the subsequent static heating process (heating the intermediate under solvent-free conditions without stirring) produces the target heterocyclic compounds via intramolecular elimination.

KEYWORDS:

heterocyclic compounds; non-stirred reaction; solvent-free synthesis; static heating; ultrasound

PMID:
29858560
DOI:
10.1002/asia.201800682

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