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J Rheumatol. 2018 Aug;45(8):1180-1187. doi: 10.3899/jrheum.171136. Epub 2018 Jun 1.

Association of Physical Activity with Late-life Mobility Limitation among Women with Total Joint Replacement for Knee or Hip Osteoarthritis.

Author information

1
From the Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine, La Jolla, California; Center for Primary Care and Prevention, Memorial Hospital of Rhode Island and Department of Family Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA. aladdinhs@yahoo.com.
2
A.H. Shadyab, PhD, Postdoctoral Fellow, Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine; C.B. Eaton, MD, MS, Professor, Center for Primary Care and Prevention, Memorial Hospital of Rhode Island and Department of Family Medicine, Warren Alpert Medical School, Brown University; W. Li, PhD, Associate Professor, Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School; A.Z. LaCroix, PhD, Professor, Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine. aladdinhs@yahoo.com.
3
From the Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine, La Jolla, California; Center for Primary Care and Prevention, Memorial Hospital of Rhode Island and Department of Family Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
4
A.H. Shadyab, PhD, Postdoctoral Fellow, Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine; C.B. Eaton, MD, MS, Professor, Center for Primary Care and Prevention, Memorial Hospital of Rhode Island and Department of Family Medicine, Warren Alpert Medical School, Brown University; W. Li, PhD, Associate Professor, Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School; A.Z. LaCroix, PhD, Professor, Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine.

Abstract

OBJECTIVE:

To examine the association between leisure-time physical activity (PA) and survival to age 85 with mobility limitation or death before age 85 after total knee (TKR) or total hip replacement (THR) for osteoarthritis (OA).

METHODS:

This was a prospective study among participants from the Women's Health Initiative (WHI), recruited 1993-1998 (baseline age 65-79 yrs) and followed through 2012. Medicare claims data were linked to WHI data to determine TKR (n = 1986) and THR (n = 1034). Self-reported PA was collected before total joint replacement (TJR).

RESULTS:

Women who were physically inactive before THR had the highest risk of mobility limitation at age 85 (OR 2.36, 95% CI 1.30-4.26) compared with women who had the highest amount of PA [> 17.42 metabolic equivalent of task (MET)-hrs/week]. Women who reported no moderate to vigorous PA (MVPA) before THR had the strongest risk of mobility limitation (OR 2.00, 95% CI 1.24-3.22) compared with women with the highest level of MPVA (≥ 15 MET-hrs/week). Women who were physically inactive before TKR had the highest risk of mobility limitation (OR 1.68, 95% CI 1.15-2.45) compared with women who had the highest PA level. Women who reported no MVPA before TKR had the strongest risk of mobility limitation (OR 1.60, 95% CI 1.16-2.19) compared with women with the highest level of MPVA. There were significant dose-response associations of lower PA levels with increased risk of late-life mobility limitation and death.

CONCLUSION:

Women with lower PA levels before TJR were more likely to experience mobility limitation in late life following TJR for hip or knee OA.

KEYWORDS:

ARTHROPLASTY; FUNCTIONAL OUTCOMES; HIP; KNEE; OSTEOARTHRITIS; PHYSICAL ACTIVITY

PMID:
29858237
PMCID:
PMC6072602
DOI:
10.3899/jrheum.171136
[Indexed for MEDLINE]
Free PMC Article

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