Format

Send to

Choose Destination
Diagn Microbiol Infect Dis. 2018 Sep;92(1):56-61. doi: 10.1016/j.diagmicrobio.2018.04.014. Epub 2018 May 16.

Characterization of group B Streptococcus isolated from sterile and non-sterile specimens in China.

Author information

1
Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China; Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.
2
Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
3
Department of Laboratory Medicine, Hubei Provincial Maternity & Child Healthcare Hospital,Wuhan, China.
4
Department of Laboratory Medicine, The university of Hong Kong-Shenzhen Hospital, Shenzhen, China.
5
Department of Laboratory Medicine, Shenzhen Children's Hospital, Shenzhen, China.
6
Department of Infectious Disease, Shenzhen Children's Hospital, Shenzhen, China.
7
Department of Laboratory Medicine, Shenzhen Guangming New District People's Hospital, Shenzhen, China.
8
Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.
9
Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: 793499131@qq.com.

Abstract

Group B streptococcus (GBS) is a leading cause of invasive neonatal infections and has increasingly been associated with invasive diseases in non-pregnant adults. We collected 113 GBS isolates recovered from sterile and non-sterile specimens from seven tertiary hospitals in China between October 2014 and September 2016. Medical records were retrospectively reviewed and the sequence types, serotypes, virulence, and antimicrobial resistance profiles of the isolates were characterized and correlated. Significantly higher C-reactive protein and procalcitonin levels and absolute neutrophil counts were observed in patients with invasive infections than in those with non-invasive infections (P < 0.05). The 113 isolates were grouped into 24 sequence types, 5 clonal complexes, and 6 serotypes. multivariate analysis revealed that clonal complex 17 isolates characterized by serotype iii, the surface protein gene rib, and the pilus island pi-2b were independently correlated with invasive infection (or: 6.79; 95% ci: 2.31-19.94, P < 0.001). These results suggest alternative molecular biomarkers for diagnosis and prognosis of GBS infections.

KEYWORDS:

Clonal complex; Group B Streptococcus; Multilocus sequence typing; Serotyping; Virulence factor

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center