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Trends Cell Biol. 2018 Dec;28(12):987-998. doi: 10.1016/j.tcb.2018.05.003. Epub 2018 May 29.

Neural Crossroads in the Hematopoietic Stem Cell Niche.

Author information

1
Center for Stem Cell and Regenerative Medicine, Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
2
Center for Stem Cell and Regenerative Medicine, Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address: otamplin@uic.edu.

Abstract

The hematopoietic stem cell (HSC) niche supports steady-state hematopoiesis and responds to changing needs during stress and disease. The nervous system is an important regulator of the niche, and its influence is established early in development when stem cells are specified. Most research has focused on direct innervation of the niche, however recent findings show there are different modes of neural control, including globally by the central nervous system (CNS) and hormone release, locally by neural crest-derived mesenchymal stem cells, and intrinsically by hematopoietic cells that express neural receptors and neurotransmitters. Dysregulation between neural and hematopoietic systems can contribute to disease, however new therapeutic opportunities may be found among neuroregulator drugs repurposed to support hematopoiesis.

KEYWORDS:

Hematopoietic stem cells; hematopoiesis; nervous system; neural; neuronal; stem cell niche

PMID:
29857963
PMCID:
PMC6822267
DOI:
10.1016/j.tcb.2018.05.003
[Indexed for MEDLINE]
Free PMC Article

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