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Microb Pathog. 2018 Aug;121:293-302. doi: 10.1016/j.micpath.2018.05.046. Epub 2018 May 29.

Developments in strategies for Quorum Sensing virulence factor inhibition to combat bacterial drug resistance.

Author information

1
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan, 45142, Saudi Arabia. Electronic address: shafiul.haque@hotmail.com.
2
Department of Public Health, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.
3
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan, 45142, Saudi Arabia.
4
Department of Emergency Medical Services, College of Applied Medical Sciences, Jazan University, Jazan, 45142, Saudi Arabia.
5
Department of Clinical Laboratory Science, College of Applied Medical Sciences, University of Ha'il, Ha'il, 2440, Saudi Arabia.
6
Department of Biotechnology, Institute of Engineering & Technology, Lucknow, 226021, Uttar Pradesh, India.
7
Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha, 65431, Saudi Arabia.

Abstract

Quorum sensing (QS) is a complex bacterial intercellular communication system. It is mediated by molecules called auto-inducers (AIs) and allows coordinated responses to a variety of environmental signals by inducing alterations in gene expression. Communication through QS can tremendously stimulate the pathogenicity and virulence via multiple mechanisms in pathogenic bacteria. The present review explores the major types of multitudinous QS systems known in Gram-positive and Gram-negative bacteria and their roles in bacterial pathogenesis and drug resistance. Because bacterial resistance to antibiotics is increasingly becoming a significant clinical challenge to human health; alternate strategies to combat drug resistance are warranted. Targeting bacterial pathogenicity by interruptions in QS using natural QS inhibitors and synthetic quorum-quenching analogs are being increasingly considered for development of next generation antimicrobials. The review highlights the recent advancements in discovery of promising new QS modulators and their efficiency in controlling infections caused by multidrug-resistant bacterial pathogens.

KEYWORDS:

Antimicrobials; Autoinducers; Drug-resistance; Pathogenesis; Quorum quenching

PMID:
29857121
DOI:
10.1016/j.micpath.2018.05.046
[Indexed for MEDLINE]

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