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Pediatr Blood Cancer. 2018 Sep;65(9):e27251. doi: 10.1002/pbc.27251. Epub 2018 Jun 1.

Age dependency of primary tumor sites and metastases in patients with Ewing sarcoma.

Author information

1
Department of Pediatric Hematology/Oncology, University Hospital Muenster, Westfalian Wilhelms University Muenster, Münster, Germany.
2
University Hospital Essen, Pediatrics III, Sarcoma Centre, West German Cancer, Essen, Germany.
3
German Cancer Consortium (DKTK), Center Essen, Germany.
4
Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts.
5
Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany.

Abstract

BACKGROUND:

The median age of patients with Ewing sarcoma (EwS) at diagnosis is around 14-15 years. Older age is associated with a worse outcome. The correlation of age at diagnosis on sites of disease has not been fully described.

OBJECTIVE:

The goal of this study was to evaluate the differences in sites of primary tumor and metastatic tumor involvement according to age groups.

DESIGN/METHOD:

EwS data from the Gesellschaft für Pädiatrische Onkologie und Hämatology (GPOH) database of the Cooperative Ewing Sarcoma Study (CESS) 81/86 and the European Intergroup Cooperative Ewing's Sarcoma Study EICESS 92 and the EUROpean Ewing tumor Working Initiative of National Groups-99-Protocol (EURO-E.W.I.N.G.-99) study were analyzed. Patient and tumor characteristics were evaluated statistically using chi square tests.

RESULTS:

The study population included 2,635 patients with bone EwS. Sites of primary and metastatic tumors differed according to the age groups of young children (0-9 years), early adolescence (10-14 years), late adolescence (15-19 years), young adults (20-24 years), and adults (more than 24 years). Young children demonstrated the most striking differences in site of disease with a lower proportion of pelvic primary and axial tumors. They presented less often with metastatic disease at diagnosis.

CONCLUSIONS:

Site of primary and metastatic tumor involvement in EwS differs according to patient age. The biological and developmental etiology for these differences requires further investigations.

KEYWORDS:

Ewing sarcoma; age; metastasis; primary tumor site

PMID:
29856530
DOI:
10.1002/pbc.27251
[Indexed for MEDLINE]

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