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Transpl Infect Dis. 2018 Oct;20(5):e12937. doi: 10.1111/tid.12937. Epub 2018 Jun 15.

Ureaplasma and Mycoplasma in kidney allograft recipients-A case series and review of the literature.

Author information

1
Division of Nephrology, University Hospital Zurich, Zurich, Switzerland.
2
Division of Nephrology, Kantonsspital Aarau, Aarau, Switzerland.
3
Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
4
Department of Radiology, Ospedale San Giovanni, Bellinzona, Switzerland.
5
Division of Nephrology, Ospedale San Giovanni, Bellinzona, Switzerland.
6
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
7
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
8
Department of Internal Medicine, Cantonal Hospital Graubuenden, Chur, Switzerland.

Abstract

Ureaplasma urealyticum and Mycoplasma hominis are common inhabitants of the human genital tract. Increasingly, serious and sometimes fatal infections in immunocompromised hosts have been reported, highlighting their pathogenic potential. We reviewed the clinical impact of positive Ureaplasma spp. and Mycoplasma spp. urine cultures in 10 renal allograft recipients who presented with sterile leukocyturia. Five recipients remained asymptomatic. Five patients were symptomatic with dysuria or pain at the graft site. Three patients developed biopsy-proven acute graft pyelonephritis with graft dysfunction. One of these patients additionally showed a renal abscess as demonstrated by magnetic resonance imaging (MRI). All were successfully treated. A literature search revealed a substantial number of case reports with severe and sometimes fatal Ureaplasma spp. or Mycoplasma spp. infections in immunocompromised patients. Colonization rate is high in renal transplant patients. A subset of patients is at risk for invasive disease.

KEYWORDS:

Mycoplasma hominis ; Ureaplasma urealyticum ; abscess; graft dysfunction; infection; kidney allograft recipient

PMID:
29856498
DOI:
10.1111/tid.12937
[Indexed for MEDLINE]

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