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J Dermatol. 2018 Sep;45(9):1141-1144. doi: 10.1111/1346-8138.14484. Epub 2018 May 31.

Mild hyperbaric oxygen activates the proliferation of epidermal basal cells in aged mice.

Author information

1
Core Technology, Kao Corporation, Tokyo, Japan.
2
Skin Care Research Laboratory, Kao Corporation, Tokyo, Japan.
3
Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.

Abstract

The proliferation of epidermal basal cells decreases with age. This study examined the effects of exposure to mild hyperbaric oxygen on the proliferative activity of epidermal basal cells in aged mouse skin. Hairless mice aged 5, 34 and 55 weeks were exposed to mild hyperbaric oxygen at 1266 hPa with 36% oxygen for 6 h/day for 1 or 2 weeks. Skin samples were then collected from the back area to evaluate epidermal thickness and the number and proliferative activity of epidermal basal cells. Exposure to mild hyperbaric oxygen had no effect on the epidermal thickness, irrespective of age, but accelerated the proliferative activity of epidermal basal cells in aged mouse skin.

KEYWORDS:

epidermal basal cell; hairless mouse; mild hyperbaric oxygen; oxidative metabolism; proliferation

PMID:
29855082
DOI:
10.1111/1346-8138.14484
[Indexed for MEDLINE]

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