Format

Send to

Choose Destination
Biomed Res Int. 2018 Apr 30;2018:1809091. doi: 10.1155/2018/1809091. eCollection 2018.

Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study.

Author information

1
Orthopaedic and Traumatology Department, "S. Anna" Hospital, University of Ferrara, Ferrara, Italy.
2
Orthopaedic and Traumatology Department, IRCCS Foundation "San Matteo" Hospital, University of Pavia, Pavia, Italy.
3
Orthopaedic and Traumatology Department, "Santo Spirito in Sassia" Hospital, Rome, Italy.
4
Research and Development, IGEA Clinical Biophysics, Carpi, Modena, Italy.
5
Orthopaedic and Traumatology Department, "Sant'Andrea" Hospital, Rome, Italy.
6
Health Sciences Department, Operative Unit of Orthopaedics and Traumatology, "San Paolo" Hospital, University of Milan, Milan, Italy.
7
Orthopaedic, Traumatology and Rehabilitation Department, II Orthopaedics Clinic, CTO Hospital, Torino, Italy.
8
Orthopaedic Department, University of Cagliari, Cagliari, Italy.
9
Orthopaedic and Traumatology Department, "Paolo Giaccone" Hospital, University of Palermo, Palermo, Italy.
10
Department of Orthopaedic Surgery, Rizzoli Orthopaedic Institute, University of Bologna, Bologna, Italy.
11
Translational Research on New Surgical and Medical Technologies Department, Orthopaedics and Traumatology II°, University of Pisa, Pisa, Italy.
12
Orthopaedics and Traumatology Clinic, "S. M. alle Scotte" Hospital, University of Siena, Siena, Italy.
13
Clinical and Molecular Science Department, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy.
14
Basic Medical Science, Neurosciences and Sensory Organs Department, University of Bari, Bari, Italy.
15
Orthopaedic and Trauma Department, "Morgagni-Pierantoni" Hospital, Forlì, Italy.
16
Orthopaedic and Traumatology Department, "Misericordia" Hospital ASL 9, Grosseto, Italy.
17
Surgery Department, "Vittorio Emanuele" Hospital, University of Catania, Catania, Italy.
18
Orthopaedic and Trauma Department, "San Michele" Nursing Home Hospital, Maddaloni, Caserta, Italy.
19
Orthopaedic and Traumatology Department, "Sandro Pertini" Hospital, ASL RMB, Rome, Italy.
20
Orthopaedic and Traumatology Department, "San Bortolo" Hospital, Vicenza, Italy.
21
Orthopaedic and Traumatology Department, A.O. Pavia Voghera Hospital, Pavia, Italy.
22
Orthopaedic and Traumatology Unit, Ariano Irpino Hospital, Avellino, Italy.
23
Orthopaedics and Trauma Department, "Papa Giovanni XXIII" Hospital, Bergamo, Italy.
24
Orthopaedic and Traumatology Department, "M. Bufalini" Hospital, Cesena, Italy.
25
Orthopaedic and Traumatology Department, "Guglielmo da Saliceto" Hospital, Piacenza, Italy.
26
Traumatology and Reconstructive Surgery Functional Department, "S. Anna" Hospital, Como, Italy.
27
Orthopaedics and Traumatology Clinic, "S. M. Misericordia" Hospital, University of Perugia, Perugia, Italy.
28
Orthopaedic Surgery Department, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy.
29
Orthopaedic and Traumatology Department, Montecchio Maggiore Hospital, Vicenza, Italy.
30
Orthopaedic and Traumatology Department, CTO Hospital ASL RM "C", Rome, Italy.
31
Orthopaedic and Traumatology Department, Regione Veneto Azienda ULSS 18, Rovigo, Italy.
32
Orthopaedics and Traumatology Department, "Di Venere" Hospital, Bari, Italy.
33
Orthopaedics and Traumatology Department, "SS. Annunziata" Hospital, Taranto, Italy.
34
Orthopaedic and Traumatology SCDU Department, "Mauriziano Umberto I" Hospital, University of Torino, Torino, Italy.
35
Orthopaedic and Traumatology Surgery Department, "San Donato" Hospital, Arezzo, Italy.
36
Orthopaedics Department, NOCSAE Hospital, Modena, Italy.
37
Orthopaedics and Traumatology Department, "Santa Chiara" Hospital, Trento, Italy.
38
Orthopaedics Unit, "Santa Maria di Loreto Mare" Hospital, Loreto Mare, Napoli, Italy.
39
Specialized Surgery Department, "S. Maria delle Croci" Hospital, Ravenna, Italy.
40
Orthopaedic Department, Sapienza University of Rome, Rome, Italy.
41
Orthopaedic and Trauma Department, "Santa Maria della Misericordia" Hospital, AOUD Udine, Udine, Italy.
42
Orthopaedics and Traumatology Unit, Piedimonte Matese Hospital, Caserta, Italy.

Abstract

Background:

Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time.

Methods:

The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain.

Results:

319 fractures (88%) healed within 12 months from treatment. Forty-four fractures healed after 12 months or underwent a second surgery. FRACTING score positively correlated with days to healing: r = 0.63 (p < 0.0001). Average score value was 7.3 ± 2.5; ROC analysis showed strong reliability of the score in separating patients healing before versus after 6 months: AUC = 0.823.

Conclusions:

This study shows that the FRACTING score can be employed both to predict months needed for fracture healing and to identify immediately after treatment patients at risk of prolonged healing. In patients with high score values, new pharmacological and nonpharmacological treatments to enhance osteogenesis could be tested selectively, which may finally result in reduced disability time and health cost savings.

PMID:
29854729
PMCID:
PMC5952440
DOI:
10.1155/2018/1809091
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Publishing Corporation Icon for PubMed Central
Loading ...
Support Center