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Toxicol Rep. 2017 Dec 16;5:76-84. doi: 10.1016/j.toxrep.2017.12.013. eCollection 2018.

Bisphenol A (BPA) the mighty and the mutagenic.

Author information

1
Department of Cellular and Molecular Pharmacology, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Tianjin, 300072, Nankai district, People's Republic of China.
2
Coorg Institute of Dental Sciences, Virajpet, Coorg, 571218, India.

Abstract

Bisphenol A (BPA) is one of the most widely used synthetic compounds on the planet. Upon entering the diet, its highest concentration (1-104 ng/g of tissue) has been recorded in the placenta and fetus. This accumulation of BPA can have many health hazards ranging from the easy to repair single strand DNA breaks (SSBs) to error prone double strand DNA breaks (DSBs). Although the Human liver can efficiently metabolize BPA via glucuronidation and sulfation pathways, however the by-product Bisphenol-o-quinone has been shown to act as a DNA adduct. Low doses of BPA have also been shown to interact with various signaling pathways to disrupt normal downstream signaling. Analysis has been made on how BPA could interact with several signaling pathways such as NFκB, JNK, MAPK, ER and AR that eventually lead to disease morphology and even tumorigenesis. The role of low dose BPA is also discussed in dysregulating Ca2+ homeostasis of the cell by inhibiting calcium channels such as SPCA1/2 to suggest a new direction for future research in the realms of BPA induced disease morphology and mutagenicity.

KEYWORDS:

BISPHENOL A (BPA) CCID: 6623; Bisphenol A (BPA); Ca2+ homeostasis; Cancer; DES, diethyl stilbesterol; DNA damage; EFSA, European Food Safety Authority; ELISA, enzyme linked immunosorbent assay; FAO/WHO, Food and Agricultural Organization/World Health Organization; FDA, Food and Drugs Administration; GC–MS, gas chromatography–mass spectrometry; HPLC, high-performance liquid chromatography; IGF1R; IGF1R, insulin-like growth factor 1 receptor; LLE, liquid/liquid extraction; MS, mass spectrometry; Mutations; SPCA1 inhibition; SPCA1, secretory pathway calcium ATPase1; SPE, solid phase extraction

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