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Clin Epigenetics. 2018 May 29;10:70. doi: 10.1186/s13148-018-0503-2. eCollection 2018.

Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer.

Vedeld HM1,2, Nesbakken A2,3,4, Lothe RA1,2,4, Lind GE1,2,5.

Author information

1
1Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Norwegian Radium Hospital, Oslo, Norway.
2
2K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway.
3
4Department of Gastrointestinal Surgery, Oslo University Hospital-Aker, Oslo, Norway.
4
5Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
5
3Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Abstract

We have previously shown that aberrant promoter methylation of ZNF331 is a potential biomarker for colorectal cancer detection with high sensitivity (71%) and specificity (98%). This finding was recently confirmed by others, and it was additionally suggested that promoter methylation of ZNF331 was an independent prognostic biomarker for colorectal cancer (n = 146). In the current study, our initial colorectal cancer sample series was extended to include a total of 423 cancer tissue samples. Aberrant promoter methylation was found in 71% of the samples, thus repeatedly suggesting the biomarker potential of ZNF331 for detection of colorectal cancer. Furthermore, multivariate Cox's analysis indicated a trend towards inferior overall survival for colorectal cancer patients with aberrant methylation of ZNF331.

KEYWORDS:

Colorectal cancer; DNA methylation; Diagnosis; Prognosis; ZNF331

Conflict of interest statement

The research biobanks have been registered according to national legislation (numbers 2781 and 236-2005-16141). The study is part of a project approved by the Regional Committee (REC) for Medical and Health Research Ethics (numbers 1.2005.1629 and S-09282c 2009/4958).RAL and GEL are inventors of a US provisional patent application filed in 2011, describing methylation of ZNF331 and five additional genes as biomarkers for detection of gastrointestinal cancers (61/451,198, INVEN-31899/US-1/PRO). The rest of the authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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