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Int J Biol Macromol. 2018 Oct 1;117:659-664. doi: 10.1016/j.ijbiomac.2018.05.203. Epub 2018 May 28.

Protective effect of an arabinogalactan from black soybean against carbon tetrachloride-induced acute liver injury in mice.

Author information

1
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China; Xuzhou Institute of Agricultural Sciences in Jiangsu Xuhuai District, Xuzhou 221131, China.
2
College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.
3
College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China. Electronic address: junliu@yzu.edu.cn.
4
College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China. Electronic address: chjin@yzu.edu.cn.

Abstract

In vivo hepatoprotective effect of a novel arabinogalactan (AG) from black soybean on carbon tetrachloride (CCl4)-induced acute liver injury was evaluated for the first time. Our results showed that administration of AG could significantly attenuate the increase in the levels of alkaline phosphatase, alanine transaminase and aspartate transaminase in the serum caused by CCl4 treatment. AG treatment not only significantly elevated the levels of antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase; but also increased the levels of non-enzyme antioxidants (glutathione and total antioxidant capacity in liver tissues) when compared with CCl4-induced acute liver injury model. In addition, AG significantly reduced lipid peroxidation levels in liver tissues. The hepatoprotective effect of high-dose of AG was comparable to that of silymarin, which served as a positive standard. This study indicated that AG had a protective effect on CCl4-induced acute liver injury.

KEYWORDS:

Arabinogalactan; Black soybean; Hepatoprotective effect; Polysaccharide

PMID:
29852225
DOI:
10.1016/j.ijbiomac.2018.05.203
[Indexed for MEDLINE]

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