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Neurodegener Dis Manag. 2018 Jun;8(3):151-159. doi: 10.2217/nmt-2017-0055. Epub 2018 May 31.

Effect of tetrahydrocannabinol:cannabidiol oromucosal spray on activities of daily living in multiple sclerosis patients with resistant spasticity: a retrospective, observational study.

Author information

1
Unidad de Neurología, Hospital General de Elda, Elda (Alicante), Spain.

Abstract

AIM:

To examine evolution in activities of daily living (ADL) in patients with multiple sclerosis spasticity during long-term use of tetrahydrocannabinol (THC):cannabidiol (CBD) oromucosal spray.

METHODS:

Functional impairment was assessed retrospectively (prior to start of treatment) and at the present moment using a 16-item ADL survey; results were compared. A control group without add-on THC:CBD oromucosal spray was included to investigate possible recall bias.

RESULTS:

ADL was maintained or slightly improved with THC:CBD oromucosal spray across treatment time (mean 31.9 months) including significant improvement in 'standing up' (p < 0.05) and trends in other items. Significant improvements (p < 0.01) with THC:CBD oromucosal spray were observed in several multiple sclerosis spasticity-related symptoms. Overall, 96.9% of patients using THC:CBD oromucosal spray had a positive global impression of change during treatment.

CONCLUSION:

In this pilot study, THC:CBD oromucosal spray maintained or improved aspects of daily functioning. Further study in a larger trial is warranted.

KEYWORDS:

THC:CBD oromucosal spray; activities of daily living; multiple sclerosis; spasticity

PMID:
29851356
DOI:
10.2217/nmt-2017-0055
[Indexed for MEDLINE]

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