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Carcinogenesis. 2018 May 30. doi: 10.1093/carcin/bgy074. [Epub ahead of print]

miR-331-3p Functions as an Oncogene by Targeting ST7L in Pancreatic Cancer.

Chen X1,2,3, Luo H2, Li X4, Tian X1, Peng B1, Liu S4,5, Zhan T1, Wan Y2, Chen W4,5,3, Li Y4,6, Lu Z4,5, Huang X1.

Author information

1
Department of Gastroenterology, Tongren hospital of WuHan University (WuHan Third Hospital), Wuhan, China.
2
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
3
Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
4
Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
5
Cancer Research Institute of Wuhan, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
6
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Abstract

Pancreatic cancer (PC) is a highly invasive tumor with early metastasis and poor prognosis, yet the mechanisms for tumor progression have not been fully elucidated. Emerging evidence indicate that microRNA-331-3p (miR-331-3p) plays an important role in the progression of diverse human cancers. Here, we found that miR-331-3p was significantly upregulated in tumor specimens of PC patients and PC cell lines. Functional studies showed that downregulation of miR-331-3p inhibited PC cell proliferation and epithelial to mesenchymal transition-mediated metastasis in vitro. Furthermore, suppression of tumorigenicity 7 like (ST7L) was identified as a novel target gene of miR-331-3p. Tumor promotion effects of miR-331-3p was partially reversed by ST7L re-expression. In addition, miR-331-3p antagomir suppressed PC tumor growth and metastasis via upregulation of ST7L in xenograft mice. In summary, these results demonstrate that miR-331-3p is a tumor-promoting miRNA in PC cells and a promising biomarker for PC.

PMID:
29850766
DOI:
10.1093/carcin/bgy074

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