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Biomed Res Int. 2018 Apr 11;2018:9625936. doi: 10.1155/2018/9625936. eCollection 2018.

Pruritus: Progress toward Pathogenesis and Treatment.

Author information

1
Department of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
2
Department of Anatomy, Southwest Medical University, Luzhou 646000, China.
#
Contributed equally

Abstract

Pruritus, the most common cutaneous symptom, is widely seen in many skin complaints. It is an uncomfortable feeling on the skin and sometimes impairs patients' quality of life. At present, the specific mechanism of pruritus still remains unclear. Antihistamines, which are usually used to relieve pruritus, ineffectively work in some patients with itching. Recent evidence has suggested that, apart from histamine, many mediators and signaling pathways are involved in the pathogenesis of pruritus. Various therapeutic options for itching correspondingly have been developed. In this review, we summarize the updated pathogenesis and therapeutic strategies for pruritus.

PMID:
29850592
PMCID:
PMC5925168
DOI:
10.1155/2018/9625936
[Indexed for MEDLINE]
Free PMC Article

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