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Curr Med Chem. 2018 May 29. doi: 10.2174/0929867325666180530094819. [Epub ahead of print]

Triglyceride-rich lipoproteins as a source of proinflammatory lipids in the arterial wall.

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Wihuri Research Institute, Helsinki. Finland.
RISE Research Institutes of Sweden Boras. Sweden.


Apolipoprotein B -containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial wall, where they accumulate and induce the formation of atherosclerotic lesions. The processes that lead to accumulation of lipoprotein-derived lipids in the arterial wall have been largely studied with focus on the low-density lipoprotein particles. However, recent observational and genetic studies have discovered that the triglyceride-rich lipoproteins and their remnants are linked with cardiovascular disease risk. In this review, we describe the potential mechanisms by which the triglyceride-rich remnant lipoproteins can contribute to the development of atherosclerotic lesions, and highlight the differences in the atherogenicity between low-density lipoproteins and the remnant lipoproteins.


Chylomicron; VLDL; atherosclerosis; cholesterol; inflammation; remnant; triglyceride

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